A medication activity (templateId 2.16.840.1.113883.10.20.1.24) SHALL be represented with SubstanceAdministration The value for “SubstanceAdministration / moodCode” in a medication activity SHALL be “EVN” or “INT” 2.16.840.1.113883.5.1001 ActMood STATIC. A medication activity SHALL contain at least one SubstanceAdministration / id. The value for “entryRelationship / typeCode” in a relationship between a medication activity and reaction observation SHALL be “CAUS” “Is etiology for” 2.16.840.1.113883.5.1002 ActRelationshipType STATIC. A medication activity SHOULD contain exactly one SubstanceAdministration / statusCode. A medication activity SHOULD contain one or more SubstanceAdministration / effectiveTime elements, used to indicate the actual or intended start and stop date of a medication, and the frequency of administration. A medication activity SHOULD contain exactly one SubstanceAdministration / routeCode. A medication activity SHOULD contain exactly one SubstanceAdministration / doseQuantity.